Prime Medicine, Inc. (PRME) vs Rigel Pharmaceuticals, Inc. (RIGL)

Prime Medicine, Inc. and Rigel Pharmaceuticals, Inc. are both Biotechnology companies. Prime Medicine, Inc. and Rigel Pharmaceuticals, Inc. are of similar size ($853.9M and $807.1M). Prime Medicine, Inc. has negative trailing earnings, so its P/E is not meaningful; Rigel Pharmaceuticals, Inc. trades at 2.4×. Rigel Pharmaceuticals, Inc. grew revenue faster over the last twelve months: 2.18% against −17.9%. Rigel Pharmaceuticals, Inc. has the higher net margin (106.6% vs −4,613.1%) and the higher return on invested capital (13.7% vs 0.00%). Across the 16 metrics below, Rigel Pharmaceuticals, Inc. leads on 14 and Prime Medicine, Inc. on 2.

Valuation

Metric PRME RIGL Biotechnology median
P/E n/m 2.35 10.60
P/S 200.59 2.57 9.40
P/B 20.52 1.66 2.13
Price to free cash flow n/m 37.96 25.18
EV/EBITDA n/m 8.30 0.66
EV/Sales 177.25 2.28 9.02
Earnings yield (23.95%) 42.49% (32.88%)
Free cash flow yield (19.20%) 2.63% (23.13%)

Profitability

Metric PRME RIGL Biotechnology median
Gross margin 100.00% 89.64% 68.51%
Operating margin (4,824.94%) 26.28% 0.00%
Net margin (4,613.11%) 106.59% 0.00%
Free cash flow margin (3,850.92%) 31.20% 0.00%
Return on equity (373.29%) 109.18% (51.96%)
Return on assets (71.16%) 80.16% (46.06%)
Return on invested capital 0.00% 13.69% 0.00%

Growth

Metric PRME RIGL Biotechnology median
Revenue growth (TTM) (17.90%) 2.18% 6.76%
EPS growth (last fiscal year) 18.18% 1,867.68% 29.88%
Revenue growth, 5-year CAGR — 22.06% 9.75%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric PRME RIGL Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 3.05 2.39 4.97
Net debt to EBITDA 0.88 (1.05) 1.01

Dividend

Metric PRME RIGL Biotechnology median
Dividend yield — — 0.41%
Payout ratio — — —

Size

Metric PRME RIGL Biotechnology median
Market cap 807.12m 853.86m 161.82m

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