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Bicycle Therapeutics PLC Sponsored ADR (BCYC) vs Upstream Bio, Inc. (UPB)

Bicycle Therapeutics PLC Sponsored ADR and Upstream Bio, Inc. are both Biotechnology companies. Bicycle Therapeutics PLC Sponsored ADR and Upstream Bio, Inc. are of similar size ($182.5M and $176.9M). Bicycle Therapeutics PLC Sponsored ADR grew revenue faster over the last twelve months: 194.8% against 16.0%. Bicycle Therapeutics PLC Sponsored ADR has the higher net margin (−169.8% vs −4,955.7%) and the higher return on invested capital (−279.8% vs −1,100.9%). Across the 16 metrics below, Bicycle Therapeutics PLC Sponsored ADR leads on 11 and Upstream Bio, Inc. on 5.

Valuation

Metric BCYC UPB Biotechnology median
P/E n/m n/m 10.60
P/S 3.02 55.81 9.40
P/B 0.50 0.65 2.13
Price to free cash flow n/m n/m 25.18
EV/EBITDA 1.28 0.50 0.66
EV/Sales (2.35) (26.93) 9.02
Earnings yield (56.22%) (89.78%) (32.88%)
Free cash flow yield (70.08%) (77.55%) (23.13%)

Profitability

Metric BCYC UPB Biotechnology median
Gross margin 100.00% 100.00% 68.51%
Operating margin (189.43%) (5,382.65%) 0.00%
Net margin (169.75%) (4,955.67%) 0.00%
Free cash flow margin (211.95%) (4,317.42%) 0.00%
Return on equity (25.24%) (46.05%) (51.96%)
Return on assets (21.30%) (44.61%) (46.06%)
Return on invested capital (279.76%) (1,100.93%) 0.00%

Growth

Metric BCYC UPB Biotechnology median
Revenue growth (TTM) 194.75% 15.98% 6.76%
EPS growth (last fiscal year) (8.97%) 52.33% 29.88%
Revenue growth, 5-year CAGR 47.52% — 9.75%
Net income growth, 5-year CAGR 0.00% — 0.00%

Health

Metric BCYC UPB Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 12.09 27.99 4.97
Net debt to EBITDA 2.61 2.11 1.01

Dividend

Metric BCYC UPB Biotechnology median
Dividend yield — — 0.41%
Payout ratio — — —

Size

Metric BCYC UPB Biotechnology median
Market cap 182.52m 176.91m 161.82m

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