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Annexon, Inc. (ANNX) vs Gyre Therapeutics, Inc. (GYRE)

Annexon, Inc. and Gyre Therapeutics, Inc. are both Biotechnology companies. Annexon, Inc. and Gyre Therapeutics, Inc. are of similar size ($682.5M and $678.6M). Annexon, Inc. has the higher net margin (0.00% vs −13.7%) and the higher return on invested capital (0.00% vs −8.51%). Across the 13 metrics below, Annexon, Inc. leads on 7 and Gyre Therapeutics, Inc. on 6.

Valuation

Metric ANNX GYRE Biotechnology median
P/E n/m n/m 8.50
P/S n/m 5.26 9.71
P/B 3.68 4.29 2.13
Price to free cash flow n/m n/m 20.82
EV/EBITDA n/m n/m 0.64
EV/Sales n/m 4.66 9.21
Earnings yield (34.02%) (3.29%) (33.15%)
Free cash flow yield (28.19%) (1.16%) (25.50%)

Profitability

Metric ANNX GYRE Biotechnology median
Gross margin 0.00% 94.15% 65.16%
Operating margin 0.00% (10.53%) 0.00%
Net margin 0.00% (13.73%) 0.00%
Free cash flow margin 0.00% (6.12%) 0.00%
Return on equity (105.26%) (11.75%) (56.36%)
Return on assets (79.38%) (9.08%) (48.04%)
Return on invested capital 0.00% (8.51%) 0.00%

Growth

Metric ANNX GYRE Biotechnology median
Revenue growth (TTM) — 10.72% 6.02%
EPS growth (last fiscal year) (32.67%) (60.00%) 30.26%
Revenue growth, 5-year CAGR — 40.96% 9.41%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric ANNX GYRE Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 5.53 4.26 4.72
Net debt to EBITDA 1.11 (3.74) 0.96

Dividend

Metric ANNX GYRE Biotechnology median
Dividend yield — — 0.09%
Payout ratio — — —

Size

Metric ANNX GYRE Biotechnology median
Market cap 682.49m 678.62m 135.18m

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