Alnylam Pharmaceuticals, Inc. (ALNY) vs Vertex Pharmaceuticals Incorporated (VRTX)

Alnylam Pharmaceuticals, Inc. and Vertex Pharmaceuticals Incorporated are both Biotechnology companies. Vertex Pharmaceuticals Incorporated is the larger, with a market value of $132.3B against $31.2B — 4.2× the size. Vertex Pharmaceuticals Incorporated trades at the lower P/E: 30.4× against 43.6×. Alnylam Pharmaceuticals, Inc. grew revenue faster over the last twelve months: 95.1% against 10.2%. Vertex Pharmaceuticals Incorporated has the higher net margin (35.0% vs 16.1%) and the higher return on invested capital (24.1% vs 0.00%). Across the 22 metrics below, Vertex Pharmaceuticals Incorporated leads on 16 and Alnylam Pharmaceuticals, Inc. on 6.

Valuation

Metric ALNY VRTX Biotechnology median
P/E 43.62 30.36 7.88
P/S 7.12 10.61 11.47
P/B 25.25 6.59 2.52
Price to free cash flow 41.71 35.17 21.16
EV/EBITDA 30.25 25.17 0.74
EV/Sales 6.64 10.00 10.73
Earnings yield 2.29% 3.29% (28.84%)
Free cash flow yield 2.40% 2.84% (23.03%)

Profitability

Metric ALNY VRTX Biotechnology median
Gross margin 79.65% 86.00% 65.16%
Operating margin 20.81% 37.95% 0.00%
Net margin 16.13% 35.00% 0.00%
Free cash flow margin 17.07% 30.16% 0.00%
Return on equity 96.55% 23.54% (57.72%)
Return on assets 15.30% 17.12% (49.22%)
Return on invested capital 0.00% 24.09% 0.00%

Growth

Metric ALNY VRTX Biotechnology median
Revenue growth (TTM) 95.14% 10.23% 5.64%
EPS growth (last fiscal year) 206.88% 836.54% —
Revenue growth, 5-year CAGR 49.77% 14.10% 8.40%
Net income growth, 5-year CAGR 0.00% 7.83% 0.00%

Health

Metric ALNY VRTX Biotechnology median
Debt to equity 0.75 0.00 0.00
Current ratio 3.05 3.19 4.73
Net debt to EBITDA (3.41) (1.51) 0.96

Dividend

Metric ALNY VRTX Biotechnology median
Dividend yield 2.52% — 2.10%
Payout ratio 0.00 0.00 0.00

Size

Metric ALNY VRTX Biotechnology median
Market cap 31.16b 132.32b 162.10m

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