Agenus Inc. (AGEN) vs Orchestra BioMed Holdings, Inc. (OBIO)

Agenus Inc. and Orchestra BioMed Holdings, Inc. are both Biotechnology companies. Agenus Inc. and Orchestra BioMed Holdings, Inc. are of similar size ($375.3M and $366.0M). Orchestra BioMed Holdings, Inc. has negative trailing earnings, so its P/E is not meaningful; Agenus Inc. trades at 3.2×. Orchestra BioMed Holdings, Inc. grew revenue faster over the last twelve months: 986.1% against 30.5%. Agenus Inc. has the higher net margin (69.2% vs −186.3%) and the higher return on invested capital (0.00% vs 0.00%). Across the 15 metrics below, Agenus Inc. leads on 12 and Orchestra BioMed Holdings, Inc. on 3.

Valuation

Metric AGEN OBIO Biotechnology median
P/E 3.23 n/m 7.88
P/S 2.66 11.87 11.47
P/B n/m 19.65 2.52
Price to free cash flow n/m n/m 21.16
EV/EBITDA 9.48 n/m 0.74
EV/Sales 2.92 9.52 10.73
Earnings yield 30.99% (14.29%) (28.84%)
Free cash flow yield (27.80%) (15.57%) (23.03%)

Profitability

Metric AGEN OBIO Biotechnology median
Gross margin 99.52% 99.51% 65.16%
Operating margin 27.28% (181.36%) 0.00%
Net margin 69.18% (186.30%) 0.00%
Free cash flow margin (73.97%) (184.83%) 0.00%
Return on equity (33.86%) (607.32%) (57.72%)
Return on assets 51.30% (75.16%) (49.22%)
Return on invested capital 0.00% 0.00% 0.00%

Growth

Metric AGEN OBIO Biotechnology median
Revenue growth (TTM) 30.47% 986.14% 5.64%
EPS growth (last fiscal year) 100.00% 33.13% —
Revenue growth, 5-year CAGR 5.31% — 8.40%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric AGEN OBIO Biotechnology median
Debt to equity (0.15) 1.80 0.00
Current ratio 0.34 8.26 4.73
Net debt to EBITDA (4.10) 1.80 0.96

Dividend

Metric AGEN OBIO Biotechnology median
Dividend yield — — 2.10%
Payout ratio 0.00 0.00 0.00

Size

Metric AGEN OBIO Biotechnology median
Market cap 375.30m 366.04m 162.10m

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