Protagonist Therapeutics, Inc.

PTGX Healthcare Biotechnology

Protagonist Therapeutics, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $46.0 million, down 89.4% from fiscal 2024. In the quarter to June 2026, revenue grew 3,749.2%, EPS grew 549.1% and free cash flow grew 839.7%, each against the same quarter a year earlier.

128.75 7.80 −5.71%
Market cap
$8.8B
P/E
106×
Fwd P/E
25.0×
Dividend yield
—
F-score
4/9
Altman Z
61.55
Beneish M
−7.18
Dividend safety
n/a
Dec '16 Dec '17 Dec '18 Dec '19 Dec '20 Dec '21 Dec '22 Dec '23 Dec '24 Dec '25
Piotroski F-Score
— — — 1 4 2 4 5 5 4
P/E ratio
— 0.00 0.00 0.00 0.00 0.00 0.00 0.00 8.62 0.00
P/S ratio
— 0.00 4.87 790.27 24.22 57.91 11.62 29.23 5.47 120.66
Altman Z-Score
— 4.41 2.12 (1.37) 8.50 18.20 6.29 34.73 22.48 61.55
Altman Z″-Score (non-manufacturers)
— 3.70 4.30 (2.30) 7.92 5.94 1.99 15.38 15.80 13.41
P/FCF ratio
— 116.73 0.00 0.00 0.00 0.00 0.00 0.00 13.00 99.01
P/Operating CF
— (26.45) (14.85) (12.78) (36.75) (58.81) (16.71) 78.38 (81.45) (150.17)
Beneish M-Score
— — (1.24) 151.71 106.46 (3.31) (3.84) 405.14 29.24 (7.18)
P/B ratio
— 3.10 1.34 2.28 2.48 5.28 2.45 3.95 3.52 9.03
Price to Tangible BV
— 3.10 1.34 2.28 2.48 5.28 2.45 3.95 3.52 9.03
EV/Sales
— 0.00 0.70 256.80 13.88 46.32 6.62 21.93 4.53 108.55
EV/EBITDA
— 0.00 0.00 0.00 0.00 0.00 0.00 0.00 7.97 0.00
EV/Operating CF
— 59.46 (0.43) (1.43) (5.48) (11.75) (2.78) (14.20) 10.68 86.61
EV/FCF
— 71.81 (0.43) (1.40) (5.45) (11.63) (2.76) (14.08) 10.76 89.07
Quick Ratio
12.41 3.43 5.10 3.95 7.66 7.46 7.61 16.53 12.32 12.49
Current Ratio
12.94 3.55 5.26 4.10 7.84 7.74 7.80 16.71 12.48 12.71
Net Debt/EBITDA
2.41 3.91 3.10 1.57 4.95 2.70 1.85 3.60 (1.70) 3.49
Debt/Assets
0.00% 0.00% 0.00% 6.32% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00%
Debt/Equity
0.00 0.00 0.00 0.12 0.00 0.00 0.00 0.00 0.00 0.00
Asset Turnover
0.00 0.16 0.20 0.00 0.12 0.08 0.09 0.20 0.79 0.07
Operating CF/Net income
0.79 (0.10) 1.28 0.54 1.10 0.86 0.85 0.89 0.67 (0.44)
Capex/Depreciation
(0.80) (0.61) (0.66) (0.50) (0.17) (0.24) (0.28) 0.48 0.23 0.37
Interest Coverage
(134.98) (40.32) (16.60) (476.46) (107.89) (284.07) (32.36) — — —
ROE
(125.46%) (35.50%) (33.39%) (80.20%) (36.79%) (43.32%) (49.41%) (28.59%) 54.39% (20.18%)
ROA
(69.34%) (28.68%) (25.67%) (52.44%) (27.60%) (37.36%) (42.78%) (26.06%) 49.91% (18.42%)
ROIC
(205.27%) 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 61.64% (208.75%)
Return on Tangible Assets
(48.77%) (33.82%) (34.69%) (69.17%) (23.90%) (42.06%) (59.68%) (23.53%) 50.27% (24.28%)
Average Days of Receivables
0.00 33.04 54.14 10,673.48 30.93 20.89 0.14 60.83 138.63 0.96
Research and Development Expense of Revenue
0.00% 230.18% 192.39% 28,139.83% 260.26% 460.60% 474.83% 200.27% 31.80% 346.16%
Selling, General and Administrative Expense of Revenue
0.00% 58.71% 44.29% 6,817.75% 65.10% 99.41% 119.40% 55.82% 10.00% 97.47%
Intangible Assets out of Total Assets
0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Share Based Compensation of Revenue
0.00% 21.14% 22.37% 3,616.02% 27.59% 59.93% 91.05% 48.82% 8.64% 99.91%
Graham Net Nets
— 0.29 0.73 0.39 0.39 0.19 0.40 0.25 0.22 0.09
Graham Number
— 0.00 0.00 0.00 0.00 0.00 0.00 0.00 33.25 0.00
Earnings Yield
— (10.26%) (25.56%) (42.55%) (9.92%) (7.89%) (24.12%) (6.32%) 11.61% (2.35%)
Free Cash Flow Yield
— 0.86% (33.51%) (23.28%) (10.52%) (6.88%) (20.60%) (5.33%) 7.69% 1.01%
Revenue per Share
0.00 1.13 1.38 0.01 0.83 0.59 0.54 1.06 7.06 0.72
Operating CF per Share
(4.61) 0.22 (2.23) (1.60) (2.11) (2.33) (2.20) (1.24) 2.99 0.91
Capex per Share
(0.05) (0.04) (0.02) (0.04) (0.01) (0.02) (0.02) (0.01) (0.02) (0.02)
Free Cash Flow per Share
(4.66) 0.18 (2.25) (1.64) (2.12) (2.35) (2.22) (1.25) 2.97 0.88
Cash per Share
11.94 8.14 5.76 5.14 8.89 7.06 4.84 6.02 6.80 8.92
Shareholders Equity per Share
13.47 6.82 5.03 3.09 8.13 6.48 4.40 5.93 10.97 9.67
Interest Debt per Share
0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Book value per Share
13.47 6.82 5.03 3.09 8.13 6.48 4.40 5.93 10.97 9.67
Free Cash Flow
(30.32) 3.21 (50.43) (42.49) (72.95) (108.97) (108.93) (70.84) 182.80 56.08
Working Capital
76.81 108.39 111.35 109.91 275.37 296.72 211.90 334.30 544.24 532.13
Capital Expenditures
(0.35) (0.67) (0.49) (0.97) (0.47) (1.10) (0.79) (0.61) (1.35) (1.59)
Net Current Asset Value
76.81 107.85 110.55 70.36 270.74 293.06 210.76 334.30 522.21 524.09
EV/EBIT
— 0.00 0.00 0.00 0.00 0.00 0.00 0.00 7.78 0.00
Capex to Sales
0.00 0.03 0.02 4.19 0.02 0.04 0.03 0.01 0.00 0.03
Price to Operating Income
— 0.00 0.00 0.00 0.00 0.00 0.00 0.00 9.40 0.00
Other line items
Depreciation/Fixed assets
0.77 1.24 0.85 1.15 1.89 2.56 1.80 (1.05) (1.87) (1.13)
Cash ROIC
(18.36%) 1.21% (20.89%) (19.07%) (12.46%) (17.38%) (24.05%) (10.44%) 16.71% 4.74%
Accounts Receivable Turnover
0.00 9.89 9.66 0.04 6.24 13.71 33.73 11.99 4.96 0.56
Accounts Payable Turnover
0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Inventory Turnover
0.00 — — — — 0.00 0.00 — — —
Average Days of Payables
0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Days of Inventory on Hand
0.00 — — — — 0.00 0.00 — — —
Average Receivables
2.73 2.03 3.20 5.67 4.59 2.00 0.79 5.01 87.50 82.56
Average Payables
1.21 1.21 4.01 5.41 4.93 4.15 3.10 2.24 1.20 3.48
Average Assets
54.42 128.86 151.60 147.19 239.69 336.08 297.81 302.94 551.34 706.46
Average Common Equity
30.08 104.09 116.57 96.24 179.79 289.81 257.81 276.14 505.99 645.00

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