Prelude Therapeutics Incorporated PRLD

3.88 (0.11) (2.76%) as of 25 Sep
Market cap
$318.4M
P/E
0.0×
Insider Buys alert about insiders buying in the last 12 month

Insider Decisions

Total buys 25.00
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — — — — — 2 — — — — —
Sell — — — — — — — — — — — —
Insider Ownership 54.54%

Capital & Financial Ratios

Market Cap 318.42
Revenue 22.42
Net Income (60.49)
Free Cash Flow (33.25)
Net Debt (151.76)
Current Ratio 4.07
Debt/Equity 0.00
P/E ratio 0.00
P/S ratio 17.02
P/B ratio 2.85
Past 5Y EPS Growth (21.61%)
This Y EPS Growth 70.74%
Next Y EPS Growth (41.28%)
Next 5Y EPS Growth 57.36%
in millions of $

Dividends

Payout Ratio 0.00
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2025 Powerpack
2024 Powerpack
2023 Powerpack
2022 Powerpack
2021 Powerpack
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 233 134 103 152
Receivables — — — —
Inventory — — — —
Other — — — —
236 136 106 155
2023 2024 2025 Q'26
Payables 5 8 4 2
ST’ Debt — — — —
Other — — — —
22 26 53 38
in millions of $

Compound Annual Growth

10y 5y 3y
Sales — — —
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — (20.21%) (29.45%)

Revenue

Mar Jun Sep Dec Year
’26 5 6 — — —
’25 — — 7 6 12
in millions of $ · fiscal quarters ending in the months shown

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (22) (16) — — —
’25 (34) (26) (19) 23 (56)
’24 (32) (23) (27) (21) (103)
’23 (30) (28) (26) (24) (107)
’22 (22) (18) (20) (23) (84)
’21 (16) (20) (22) (26) (84)
’20 (10) (9) (13) (15) (46)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 (22) (16) — — —
’25 (34) (26) (19) 23 (56)
’24 (32) (23) (27) (21) (104)
’23 (31) (29) (26) (25) (111)
’22 (23) (19) (21) (23) (87)
’21 (17) (20) (22) (26) (86)
’20 (10) (9) (13) (15) (47)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (0.13) (0.14) — — —
’25 (0.42) (0.41) (0.26) (0.20) (1.29)
’24 (0.42) (0.46) (0.43) (0.38) (1.68)
’23 (0.58) (0.54) (0.45) (0.47) (2.02)
’22 (0.63) (0.58) (0.63) (0.60) (2.44)
’21 (0.47) (0.58) (0.66) (0.71) (2.43)
’20 (5.12) (5.50) (5.25) (0.45) (4.56)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
— — — — 23.69 10.96 3.87 1.66 0.80 0.61

Analyst estimates 2026–2028

Powerpack
Low Price
— — — — 89.06 95.38 13.40 8.57 6.80 4.22
High Price
— — — 51 68 116 122 128 131 79
Employees
— — — 0 0 0 0 0 0 0
Revenue/Emp
— — — — — — — — 7 12
Revenue
— — 0.00% 0.00% 0.00% 0.00% 0.00% — 100.00% 100.00%
Gross Margin
— — (15) (28) (57) (112) (115) (122) (127) (99)
EBT
— — 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% (1,816.76%) (819.59%)
EBT Margin
— 0 (15) (28) (57) (112) (115) (122) (127) (99)
Net Income
— — 0 0 1 2 4 (2) (3) 1
Depreciation
— — 0.00 0.00 0.00 0.00 0.00 0.00 0.09 0.16
Revenue/Sh
— — (0.34) (16.52) (4.56) (2.43) (2.44) (2.02) (1.68) (1.29)
Earnings/Sh
— — (0.30) (15.38) (3.70) (1.81) (1.77) (1.77) (1.36) (0.73)
Cash Flow/Sh
— — 0.00 (0.47) (0.05) (0.05) (0.06) (0.06) (0.01) 0.00
Capex/Sh
— — (0.30) (15.84) (3.75) (1.86) (1.83) (1.83) (1.37) (0.73)
Free CF/Sh
— — 0.32 10.20 17.00 6.21 4.13 3.93 1.73 0.89
Book Value/Sh
— — 44 2 12 46 47 60 76 77
Shares
— — — — — — — — 0.00 0.00
PE Ratio
— — — — — — — — 0.00 11.66
PS Ratio
— — — — — — — — 0.74 3.25
PB Ratio
— — — — — — — — 0.00 6.27
EV/Sales
— — — — — — — — 0.35 (2.13)
EV/FCF
— — (13) (26) (46) (84) (84) (107) (103) (56)
Op' Cash Flow
— — (1) (1) (1) (2) (3) (4) (1) 0
Capex
— — (13) (26) (47) (86) (87) (111) (104) (56)
FCF
— — 13 15 209 276 183 214 110 53
Working Cap'
— — — 0 — 2 2 — — —
Total Debt
— — (16) (19) (218) (291) (202) (233) (134) (103)
Net Debt
— — 14 17 212 286 195 237 131 69
Sh' Equity
— — (178.96%) (144.06%) (46.39%) (42.25%) (43.93%) (48.91%) (56.12%) (62.81%)
ROA
— — 0.00% 0.00% 0.00% 0.00% 0.00% (1,989.73%) 0.00% 0.00%
ROIC
— — 40.72% 76.47% (69.95%) (44.85%) (47.97%) (56.33%) (69.01%) (99.45%)
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Fiscal years to Dec 2025 · latest quarter Jun 2026

Prelude Therapeutics Incorporated peers in Biotechnology

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Prelude Therapeutics Incorporated (PRLD) key facts

  • Prelude Therapeutics Incorporated (PRLD) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • Prelude Therapeutics Incorporated’s revenue for fiscal 2025 (year ended December 2025) was $12.1 million, up 73.4% from fiscal 2024.
  • As of September 25, 2026, PRLD traded at $3.88, a market capitalization of $318.4 million.
  • Return on equity was −99.5% and debt-to-equity 0.00.

Source: company filings (standardised) and stockrow calculations.

Prelude Therapeutics Incorporated (PRLD) Latest News

News by impact score

Fine-tune

10 Sep

4

Prelude Therapeutics receives FDA clearance of its IND application for PRT13722, a first-in-class oral KAT6A selective degrader. FDA IND clearance advances PRT13722 into clinical development, boosting Prelude's oncology drug pipeline.

12 Aug

3

Sellas experimental drug SLS009 leads the CDK9 race according to Alliance Global, with an analyst projecting about 200% upside potential. Sellas SLS009 CDK9 leadership introduces competitive pressure that may moderately affect PRLD positioning.

11 Aug

3

Prelude Therapeutics reports second quarter 2026 financial results and provides corporate update. Quarterly financial results disclosure supplies performance data that can shift investor views and near-term valuation.

17 Jul

3

Prelude Therapeutics (PRLD) received a Buy rating upgrade. Buy upgrade influences PRLD investor sentiment and short-term trading.

12 May

3

Prelude Therapeutics Incorporated (PRLD) reported first quarter 2026 financial results and provided a corporate update. Quarterly financial results and corporate updates moderately influence financial performance and investor sentiment for biotechs.

8 May

4

Wall Street analysts forecast Prelude Therapeutics (PRLD) stock could surge 33.59%, urging investors to review details before betting. Analyst consensus targets imply 33.59% upside, likely driving significant positive investor sentiment and stock momentum.

1 May

3

Prelude Therapeutics (PRLD) presented preclinical data demonstrating the potential of its KAT6A degrader PRT13722 in breast cancer models. Preclinical data for PRT13722 in breast cancer advances Prelude's oncology pipeline and could moderately boost investor sentiment and competitive positioning.

20 Apr

3

Prelude Therapeutics presented preclinical data on PRT13722, a first-in-class, orally bioavailable, potent, and highly selective KAT6A degrader development candidate, at the AACR Annual Meeting 2026. Preclinical data on a first-in-class KAT6A degrader advances the pipeline and bolsters competitive positioning in oncology but lacks clinical validation.

15 Apr

3

Prelude Therapeutics Incorporated (PRLD) appointed Charles Morris, M.D. as Chief Medical Officer. Appointing a new Chief Medical Officer strengthens clinical leadership and may moderately influence pipeline development and investor sentiment.

10 Mar

4

Prelude Therapeutics Incorporated reported full year 2025 financial results and provided program outlook for 2026. Annual financial results disclosure combined with 2026 program outlook constitutes major strategic update likely to drive stock volatility and investor sentiment.

3 Feb

4

Prelude Therapeutics has received FDA clearance for its Investigational New Drug Application (IND) for PRT12396, a selective inhibitor targeting the JAK2V617F mutation. This marks a significant step in the development of therapies for patients with certain blood cancers, potentially enhancing treatment options in this area. FDA clearance for a new drug indicates a major strategic advancement that could significantly impact Prelude Therapeutics' market position and investor sentiment.

28 Jan

3

Prelude Therapeutics Incorporated is highlighted among promising penny stocks, alongside Definitive Healthcare and another company. The article emphasizes the potential for growth and investment opportunities in these stocks, particularly focusing on Prelude's innovative approaches in the biotech sector. Prelude's innovative strategies may moderately influence its market performance and investor sentiment.

26 Jan

3

Retail investors have significantly backed Prelude Therapeutics Incorporated (NASDAQ:PRLD), leading to a 12% increase in the stock price last week. This surge reflects the growing influence of retail investors in the market and their ability to impact stock performance. The stock price increase indicates a noticeable influence on market sentiment, but it may not fundamentally alter the company's long-term trajectory.

30 Dec

4

Prelude Therapeutics Incorporated (PRLD) is highlighted as a promising stock priced below its estimated value for December 2025. The article emphasizes the company's potential in the biotech sector, particularly its innovative approaches to cancer treatment. Analysts suggest that Prelude's pipeline and strategic initiatives could lead to significant growth, making it an attractive investment opportunity for those looking to capitalize on undervalued stocks in the market. Prelude's innovative approaches and strategic initiatives in the biotech sector are likely to significantly impact its future performance.

3

Prelude Therapeutics Incorporated (PRLD) is highlighted as one of three promising penny stocks with a market capitalization below $400 million. The company focuses on developing targeted therapies for cancer, showcasing potential for growth in the biotech sector. Investors are encouraged to consider PRLD due to its innovative approach and the overall market interest in biotech stocks. The company's focus on targeted cancer therapies may moderately influence its market performance and investor sentiment.

29 Dec

4

Prelude Therapeutics Incorporated is advancing towards profitability by focusing on its innovative cancer therapies. The company is strategically managing its resources and pipeline to enhance financial performance and market position. Recent developments indicate a commitment to achieving sustainable growth through targeted investments and partnerships, which could significantly influence its future trajectory. Strategic moves and product developments are likely to significantly impact Prelude's market position and investor sentiment.

6 Dec

4

Prelude Therapeutics Incorporated presented data at the 2025 ASH Annual Meeting regarding its Myeloproliferative Neoplasm (MPN) programs, highlighting advancements in treatment options and potential impacts on patient outcomes. The presentation of new data at a major conference indicates significant advancements that could influence investor sentiment and the company's strategic direction.

1 Dec

3

Prelude Therapeutics Incorporated (PRLD) is highlighted as a penny stock to consider in December 2025, reflecting potential investment opportunities in the biotech sector. The company is noted for its innovative approaches in drug development, particularly in oncology, which may attract investor interest. Market trends and financial performance indicators suggest a favorable outlook for PRLD, making it a candidate for investors looking for growth in the biotech space. The company's innovative drug development strategies may moderately influence its financial performance and market positioning.

12 Nov

4

Prelude Therapeutics Incorporated reported its Q3 2025 earnings, highlighting strategic partnerships that are expected to enhance its research and development capabilities. The company emphasized its commitment to advancing its pipeline of therapies and outlined future growth strategies. Financial results showed a positive trend, with increased revenue attributed to successful collaborations and ongoing clinical trials. Management expressed optimism about upcoming product launches and the potential for significant market impact. Strategic partnerships and positive financial trends are likely to significantly influence Prelude's future performance and market positioning.

3

Prelude Therapeutics Incorporated reported its financial results for the third quarter of 2025, highlighting key metrics and developments in its corporate strategy. The company provided updates on its ongoing projects and future plans, emphasizing its commitment to advancing its pipeline and enhancing shareholder value. The financial results and corporate updates indicate moderate influence on Prelude's financial performance and strategic direction.

8 Nov

4

Prelude Therapeutics has realigned its pipeline and entered a deal with Incyte, which is expected to enhance its strategic focus and financial position. The collaboration aims to leverage Incyte's expertise in drug development, potentially accelerating Prelude's growth in targeted therapies. This move comes as Prelude seeks to optimize its resources and streamline its operations, positioning itself for future advancements in oncology treatments. The partnership with Incyte and pipeline realignment are significant strategic moves that could enhance Prelude's market position and investor sentiment.

5 Nov

4

Prelude Therapeutics Incorporated (PRLD) shares rose 14.3% following a strategic option deal with Incyte and a shift in its pipeline focus. The collaboration is expected to enhance Prelude's development capabilities and potentially lead to new therapeutic advancements. Investors are evaluating whether these changes could positively influence the company's future performance and market position. The Incyte option deal and pipeline shift are significant strategic moves that could alter Prelude's trajectory and investor sentiment.

4 Nov

4

Prelude Therapeutics Incorporated announced a strategic business update, highlighting its focus on advancing its pipeline of targeted therapies for cancer. The company is prioritizing its lead programs and optimizing resource allocation to enhance development efficiency. Additionally, Prelude is exploring potential partnerships to bolster its growth and expand its market presence. The update reflects a commitment to innovation and strategic positioning within the competitive oncology landscape. The strategic focus on pipeline advancement and potential partnerships could significantly influence Prelude's market position and investor sentiment.

4

Prelude Therapeutics has entered into an exclusive option agreement with Incyte to develop mutant selective JAK2V617F JH2 inhibitors. This collaboration aims to advance innovative treatments for patients with certain hematologic malignancies, leveraging Prelude's expertise in targeted therapies. The agreement underscores Prelude's commitment to addressing unmet medical needs in oncology. The collaboration with Incyte represents a significant strategic move that could enhance Prelude's product pipeline and market position in oncology.

3 Nov

3

Prelude Therapeutics Incorporated announced the publication of abstracts for presentation at the American Society of Hematology's 67th Annual Meeting. The abstracts will highlight the company's research and developments in hematology, showcasing its commitment to advancing treatment options in this field. The publication of abstracts at a major conference may enhance visibility and interest in Prelude's research, potentially influencing market sentiment.

27 Oct

3

Prelude Therapeutics Incorporated (PRLD) is highlighted as one of three compelling penny stocks with market capitalizations under $600 million. The article emphasizes the company's innovative approach to cancer treatment and its potential for growth in the biotech sector. Investors are encouraged to consider Prelude Therapeutics due to its promising pipeline and strategic positioning in the market. Prelude Therapeutics has a promising pipeline that may moderately influence its financial performance and competitive positioning.

17 Oct

3

Prelude Therapeutics Incorporated has appointed Katina Dorton, J.D., MBA, to its Board of Directors. Dorton brings extensive experience in the biopharmaceutical industry, having held various leadership roles and served on multiple boards. Her expertise is expected to enhance Prelude's strategic direction and governance. The appointment of a seasoned professional to the board may positively influence the company's strategic decisions and governance.

26 Sep

3

Prelude Therapeutics Incorporated (PRLD) is highlighted as one of three promising penny stocks with a market cap exceeding $60 million. The article emphasizes the company's potential for growth and investment opportunities within the biotech sector, particularly in the context of its innovative drug development pipeline and strategic positioning in the market. The company's innovative drug development pipeline may moderately influence its financial performance and competitive positioning.

26 Aug

3

Prelude Therapeutics Incorporated (PRLD) is highlighted as one of three promising penny stocks with market capitalizations under $300 million. The article emphasizes the company's innovative approach to drug development, particularly in oncology, and its potential for growth in a competitive market. Investors are encouraged to consider PRLD as a viable option due to its strategic initiatives and market positioning. The company's innovative drug development strategy may moderately influence its financial performance and market positioning.

14 Aug

3

Prelude Therapeutics Incorporated reported its financial results for the second quarter of 2025, highlighting key metrics and developments in its ongoing projects. The company provided updates on its pipeline, including advancements in clinical trials and strategic initiatives aimed at enhancing its market position. Financial performance indicators showed trends that may influence future operations and investor sentiment. The financial results and updates on clinical trials indicate a moderately noticeable influence on the company's future performance and market positioning.

stockrow.com/PRLD · Data as of Jun 30, 2026 · For information only; not investment advice. · © 2026 stockrow.com