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Atrium Therapeutics, Inc. (RNA) vs Upstream Bio, Inc. (UPB)

Atrium Therapeutics, Inc. and Upstream Bio, Inc. are both Biotechnology companies. Atrium Therapeutics, Inc. and Upstream Bio, Inc. are of similar size ($185.8M and $176.9M). Atrium Therapeutics, Inc. has the higher net margin (−203.7% vs −4,955.7%) and the higher return on invested capital (0.00% vs −1,100.9%). Across the 14 metrics below, Atrium Therapeutics, Inc. leads on 9 and Upstream Bio, Inc. on 5.

Valuation

Metric RNA UPB Biotechnology median
P/E n/m n/m 10.60
P/S 5.08 55.81 9.40
P/B 0.66 0.65 2.13
Price to free cash flow n/m n/m 25.18
EV/EBITDA 2.03 0.50 0.66
EV/Sales (4.33) (26.93) 9.02
Earnings yield (40.03%) (89.78%) (32.88%)
Free cash flow yield (40.71%) (77.55%) (23.13%)

Profitability

Metric RNA UPB Biotechnology median
Gross margin 100.00% 100.00% 68.51%
Operating margin (214.60%) (5,382.65%) 0.00%
Net margin (203.67%) (4,955.67%) 0.00%
Free cash flow margin (206.99%) (4,317.42%) 0.00%
Return on equity 0.00% (46.05%) (51.96%)
Return on assets (40.74%) (44.61%) (46.06%)
Return on invested capital 0.00% (1,100.93%) 0.00%

Growth

Metric RNA UPB Biotechnology median
Revenue growth (TTM) — 15.98% 6.76%
EPS growth (last fiscal year) — 52.33% 29.88%
Revenue growth, 5-year CAGR 22.54% — 9.75%
Net income growth, 5-year CAGR 0.00% — 0.00%

Health

Metric RNA UPB Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 8.73 27.99 4.97
Net debt to EBITDA 9.08 2.11 1.01

Dividend

Metric RNA UPB Biotechnology median
Dividend yield — — 0.41%
Payout ratio — — —

Size

Metric RNA UPB Biotechnology median
Market cap 185.78m 176.91m 161.82m

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