Mesoblast Limited (MESO) vs Septerna, Inc. (SEPN)

Mesoblast Limited and Septerna, Inc. are both Biotechnology companies. Mesoblast Limited and Septerna, Inc. are of similar size ($1.8B and $1.8B). Septerna, Inc. grew revenue faster over the last twelve months: 13,520.1% against −26.5%. Septerna, Inc. has the higher net margin (−24.5% vs −1,091.7%) and the lower return on invested capital (−189.0% vs 0.00%). Across the 17 metrics below, Septerna, Inc. leads on 12 and Mesoblast Limited on 5.

Valuation

Metric MESO SEPN Biotechnology median
P/E n/m n/m 8.50
P/S 137.69 16.42 9.71
P/B 1.80 4.20 2.13
Price to free cash flow n/m 13.81 20.82
EV/EBITDA n/m n/m 0.64
EV/Sales 137.28 12.66 9.21
Earnings yield (8.43%) (1.50%) (33.15%)
Free cash flow yield (8.17%) 7.24% (25.50%)

Profitability

Metric MESO SEPN Biotechnology median
Gross margin (269.72%) 100.00% 65.16%
Operating margin (826.28%) (44.04%) 0.00%
Net margin (1,091.71%) (24.51%) 0.00%
Free cash flow margin 0.00% 118.93% 0.00%
Return on equity 0.00% (6.34%) (56.36%)
Return on assets 0.00% (4.94%) (48.04%)
Return on invested capital 0.00% (189.01%) 0.00%

Growth

Metric MESO SEPN Biotechnology median
Revenue growth (TTM) (26.54%) 13,520.11% 6.02%
EPS growth (last fiscal year) 48.24% 84.85% 30.26%
Revenue growth, 5-year CAGR 74.39% — 9.41%
Net income growth, 5-year CAGR 0.00% — 0.00%

Health

Metric MESO SEPN Biotechnology median
Debt to equity 0.22 0.00 0.00
Current ratio 1.58 4.99 4.72
Net debt to EBITDA (0.67) 5.86 0.96

Dividend

Metric MESO SEPN Biotechnology median
Dividend yield — — 0.09%
Payout ratio — — —

Size

Metric MESO SEPN Biotechnology median
Market cap 1.81b 1.75b 135.18m

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