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Compugen Ltd. (CGEN) vs Upstream Bio, Inc. (UPB)

Compugen Ltd. and Upstream Bio, Inc. are both Biotechnology companies. Compugen Ltd. and Upstream Bio, Inc. are of similar size ($185.7M and $176.9M). Upstream Bio, Inc. has negative trailing earnings, so its P/E is not meaningful; Compugen Ltd. trades at 5.2×. Compugen Ltd. grew revenue faster over the last twelve months: 234.2% against 16.0%. Compugen Ltd. has the higher net margin (47.6% vs −4,955.7%) and the higher return on invested capital (0.00% vs −1,100.9%). Across the 17 metrics below, Compugen Ltd. leads on 12 and Upstream Bio, Inc. on 5.

Valuation

Metric CGEN UPB Biotechnology median
P/E 5.16 n/m 10.60
P/S 2.51 55.81 9.40
P/B 2.09 0.65 2.13
Price to free cash flow 4.63 n/m 25.18
EV/EBITDA 1.99 0.50 0.66
EV/Sales 0.81 (26.93) 9.02
Earnings yield 19.39% (89.78%) (32.88%)
Free cash flow yield 21.58% (77.55%) (23.13%)

Profitability

Metric CGEN UPB Biotechnology median
Gross margin 86.89% 100.00% 68.51%
Operating margin 40.94% (5,382.65%) 0.00%
Net margin 47.55% (4,955.67%) 0.00%
Free cash flow margin 54.10% (4,317.42%) 0.00%
Return on equity 47.85% (46.05%) (51.96%)
Return on assets 23.86% (44.61%) (46.06%)
Return on invested capital 0.00% (1,100.93%) 0.00%

Growth

Metric CGEN UPB Biotechnology median
Revenue growth (TTM) 234.18% 15.98% 6.76%
EPS growth (last fiscal year) 337.50% 52.33% 29.88%
Revenue growth, 5-year CAGR 105.20% — 9.75%
Net income growth, 5-year CAGR 0.00% — 0.00%

Health

Metric CGEN UPB Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 5.72 27.99 4.97
Net debt to EBITDA (4.65) 2.11 1.01

Dividend

Metric CGEN UPB Biotechnology median
Dividend yield — — 0.41%
Payout ratio — — —

Size

Metric CGEN UPB Biotechnology median
Market cap 185.67m 176.91m 161.82m

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