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Alpha Cognition Inc. (ACOG) vs Upstream Bio, Inc. (UPB)

Alpha Cognition Inc. and Upstream Bio, Inc. are both Biotechnology companies. Alpha Cognition Inc. and Upstream Bio, Inc. are of similar size ($180.5M and $176.9M). Alpha Cognition Inc. has the higher net margin (−137.7% vs −4,955.7%) and the higher return on invested capital (−144.7% vs −1,100.9%). Across the 15 metrics below, Alpha Cognition Inc. leads on 8 and Upstream Bio, Inc. on 7.

Valuation

Metric ACOG UPB Biotechnology median
P/E n/m n/m 10.60
P/S 11.83 55.81 9.40
P/B 3.41 0.65 2.13
Price to free cash flow n/m n/m 25.18
EV/EBITDA n/m 0.50 0.66
EV/Sales 9.18 (26.93) 9.02
Earnings yield (11.58%) (89.78%) (32.88%)
Free cash flow yield (20.54%) (77.55%) (23.13%)

Profitability

Metric ACOG UPB Biotechnology median
Gross margin 90.37% 100.00% 68.51%
Operating margin (174.70%) (5,382.65%) 0.00%
Net margin (137.69%) (4,955.67%) 0.00%
Free cash flow margin (242.99%) (4,317.42%) 0.00%
Return on equity (49.53%) (46.05%) (51.96%)
Return on assets (38.33%) (44.61%) (46.06%)
Return on invested capital (144.65%) (1,100.93%) 0.00%

Growth

Metric ACOG UPB Biotechnology median
Revenue growth (TTM) — 15.98% 6.76%
EPS growth (last fiscal year) 42.08% 52.33% 29.88%
Revenue growth, 5-year CAGR — — 9.75%
Net income growth, 5-year CAGR 0.00% — 0.00%

Health

Metric ACOG UPB Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 9.03 27.99 4.97
Net debt to EBITDA 2.92 2.11 1.01

Dividend

Metric ACOG UPB Biotechnology median
Dividend yield — — 0.41%
Payout ratio — — —

Size

Metric ACOG UPB Biotechnology median
Market cap 180.54m 176.91m 161.82m

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