Exelixis, Inc. (EXEL) vs Madrigal Pharmaceuticals, Inc. (MDGL)

Exelixis, Inc. and Madrigal Pharmaceuticals, Inc. are both Biotechnology companies. Exelixis, Inc. is the larger, with a market value of $14.4B against $11.9B — 1.2× the size. Madrigal Pharmaceuticals, Inc. has negative trailing earnings, so its P/E is not meaningful; Exelixis, Inc. trades at 17.6×. Madrigal Pharmaceuticals, Inc. grew revenue faster over the last twelve months: 149.0% against 9.23%. Exelixis, Inc. has the higher net margin (35.3% vs −25.3%) and the higher return on invested capital (60.5% vs −787.3%). Across the 18 metrics below, Exelixis, Inc. leads on 17 and Madrigal Pharmaceuticals, Inc. on 1.