Axsome Therapeutics, Inc. (AXSM) vs Krystal Biotech, Inc. (KRYS)

Axsome Therapeutics, Inc. and Krystal Biotech, Inc. are both Biotechnology companies. Axsome Therapeutics, Inc. and Krystal Biotech, Inc. are of similar size ($10.3B and $10.2B). Axsome Therapeutics, Inc. has negative trailing earnings, so its P/E is not meaningful; Krystal Biotech, Inc. trades at 41.9×. Axsome Therapeutics, Inc. grew revenue faster over the last twelve months: 56.9% against 22.6%. Krystal Biotech, Inc. has the higher net margin (54.8% vs −24.7%) and the higher return on invested capital (24.1% vs 0.00%). Across the 17 metrics below, Krystal Biotech, Inc. leads on 14 and Axsome Therapeutics, Inc. on 3.

Valuation

Metric AXSM KRYS Biotechnology median
P/E n/m 41.86 7.88
P/S 13.01 23.21 11.47
P/B 121.31 7.52 2.52
Price to free cash flow n/m 39.65 21.16
EV/EBITDA n/m 45.87 0.74
EV/Sales 12.77 21.29 10.73
Earnings yield (1.92%) 2.39% (28.84%)
Free cash flow yield (0.71%) 2.52% (23.03%)

Profitability

Metric AXSM KRYS Biotechnology median
Gross margin 93.24% 94.64% 65.16%
Operating margin (23.96%) 44.89% 0.00%
Net margin (24.68%) 54.82% 0.00%
Free cash flow margin (9.27%) 58.52% 0.00%
Return on equity (245.10%) 20.12% (57.72%)
Return on assets (27.35%) 18.30% (49.22%)
Return on invested capital 0.00% 24.07% 0.00%

Growth

Metric AXSM KRYS Biotechnology median
Revenue growth (TTM) 56.87% 22.63% 5.64%
EPS growth (last fiscal year) 38.56% 128.00% —
Revenue growth, 5-year CAGR — — 8.40%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric AXSM KRYS Biotechnology median
Debt to equity 1.52 0.00 0.00
Current ratio 1.43 8.32 4.73
Net debt to EBITDA 1.29 (4.93) 0.96

Dividend

Metric AXSM KRYS Biotechnology median
Dividend yield — — 2.10%
Payout ratio 0.00 0.00 0.00

Size

Metric AXSM KRYS Biotechnology median
Market cap 10.27b 10.21b 162.10m

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