Q32 Bio Inc. (QTTB) vs Upstream Bio, Inc. (UPB)

Q32 Bio Inc. and Upstream Bio, Inc. are both Biotechnology companies. Q32 Bio Inc. and Upstream Bio, Inc. are of similar size ($283.2M and $282.8M). Upstream Bio, Inc. has negative trailing earnings, so its P/E is not meaningful; Q32 Bio Inc. trades at 2.9×. Upstream Bio, Inc. grew revenue faster over the last twelve months: 16.0% against −307.3%. Q32 Bio Inc. has the higher net margin (0.00% vs −4,955.7%) and the higher return on invested capital (0.00% vs −1,100.9%). Across the 14 metrics below, Q32 Bio Inc. leads on 11 and Upstream Bio, Inc. on 3.

Valuation

Metric QTTB UPB Biotechnology median
P/E 2.90 n/m 7.88
P/S n/m 92.62 11.47
P/B 1.68 1.08 2.52
Price to free cash flow n/m n/m 21.16
EV/EBITDA n/m n/m 0.74
EV/Sales (12.07) 9.87 10.73
Earnings yield 34.44% (54.10%) (28.84%)
Free cash flow yield (7.23%) (46.74%) (23.03%)

Profitability

Metric QTTB UPB Biotechnology median
Gross margin 100.00% 100.00% 65.16%
Operating margin 0.00% (5,382.65%) 0.00%
Net margin 0.00% (4,955.67%) 0.00%
Free cash flow margin 0.00% (4,317.42%) 0.00%
Return on equity 72.14% (46.05%) (57.72%)
Return on assets 37.13% (44.61%) (49.22%)
Return on invested capital 0.00% (1,100.93%) 0.00%

Growth

Metric QTTB UPB Biotechnology median
Revenue growth (TTM) (307.33%) 15.98% 5.64%
EPS growth (last fiscal year) 148.96% 52.33% —
Revenue growth, 5-year CAGR 100.32% — 8.40%
Net income growth, 5-year CAGR 0.00% — 0.00%

Health

Metric QTTB UPB Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 20.30 27.99 4.73
Net debt to EBITDA (2.21) 2.11 0.96

Dividend

Metric QTTB UPB Biotechnology median
Dividend yield — — 2.10%
Payout ratio 0.00 — 0.00

Size

Metric QTTB UPB Biotechnology median
Market cap 282.81m 283.17m 162.10m

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