GH Research PLC (GHRS) vs Septerna, Inc. (SEPN)

GH Research PLC and Septerna, Inc. are both Biotechnology companies. GH Research PLC and Septerna, Inc. are of similar size ($1.8B and $1.7B). GH Research PLC has the higher net margin (0.00% vs −24.5%) and the higher return on invested capital (0.00% vs −189.0%). Across the 13 metrics below, Septerna, Inc. leads on 8 and GH Research PLC on 5.

Valuation

Metric GHRS SEPN Biotechnology median
P/E n/m n/m 7.88
P/S n/m 17.20 11.47
P/B 4.41 4.40 2.52
Price to free cash flow n/m 14.47 21.16
EV/EBITDA n/m n/m 0.74
EV/Sales n/m 13.44 10.73
Earnings yield (4.19%) (1.43%) (28.84%)
Free cash flow yield (3.27%) 6.91% (23.03%)

Profitability

Metric GHRS SEPN Biotechnology median
Gross margin 0.00% 100.00% 65.16%
Operating margin 0.00% (44.04%) 0.00%
Net margin 0.00% (24.51%) 0.00%
Free cash flow margin 0.00% 118.93% 0.00%
Return on equity (18.79%) (6.34%) (57.72%)
Return on assets (18.16%) (4.94%) (49.22%)
Return on invested capital 0.00% (189.01%) 0.00%

Growth

Metric GHRS SEPN Biotechnology median
Revenue growth (TTM) — 13,520.11% 5.64%
EPS growth (last fiscal year) (5.33%) 84.85% —
Revenue growth, 5-year CAGR — — 8.40%
Net income growth, 5-year CAGR 0.00% — 0.00%

Health

Metric GHRS SEPN Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 28.70 4.99 4.73
Net debt to EBITDA 4.65 5.86 0.96

Dividend

Metric GHRS SEPN Biotechnology median
Dividend yield — — 2.10%
Payout ratio 0.00 — 0.00

Size

Metric GHRS SEPN Biotechnology median
Market cap 1.68b 1.78b 162.10m

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